Market Overview

The global market for downstream processing has been witnessing massive growth due to increasing spending in medical research and the expanding biopharmaceutical industry. Furthermore, the rising public-private investments and RD expenditure are also likely to impact the market growth positively. Moreover, the rising number of CMOs in the market and increasing adoption of single-use technology in bioprocessing are also expected to catalyze market growth over the assessment timeframe. However, the shortage of skilled professionals is anticipated to impede the market growth over the review timeframe.

Downstream processing is a series of operations needed to derive homogeneous and pure protein products from biological materials such as plant tissues, tissue culture fluid, or cells. As per the reports by MRFR, the downstream processing market is projected to attain a market size of USD 61,174.53 million by the end of 2027 while growing at a CAGR of over 16.09%. 

Segment Analysis

The global market for downstream processing is split into several segments based on technique, product, application, end-user, and region.

Based on the technique, the market is split into size exclusion chromatography, hydrophobic interaction, affinity exchange, ion exchange, purification techniques, clarification/concentration, solid-liquid separation, formulation, cell disruption, and others.

By product, the market is divided into membrane adsorbers, filters, chromatography columns resins, and others.

Based on application, the downstream processing market is divided into vaccine production, antibodies production, hormone production, antibiotic production, and others.

By end-user, the market is divided into research academic institutes, contract manufacturing organizations, biopharmaceutical manufacturers, and others.

Regional Analysis

The global downstream processing market is studied across five major regions: North America, Europe, Asia-Pacific, Latin America, and the Middle East Africa.

The North American regional downstream processing market led the global market in 2020, attributing to many CMOs, pharmaceutical biopharmaceutical companies, and well-established research organizations involved in RD activities. Several strategies such as product launches and mergers acquisitions implemented by the players in the region are another aspect contributing to the growth of the regional market. The region is anticipated to continue dominating the global market during the assessment timeframe, given the increase in RD investments by private and public players in the healthcare sector.

The European regional market for downstream processing is primarily driven by the increasing RD expenditure by biopharmaceutical companies, a wide number of market players, and growing investment in the RD sector in the region.

The Asia-Pacific downstream processing market is projected to record the highest growth over the forecasted era owing to the increasing investments in biotechnology, the establishment of research organizations, and speedily developing and improving healthcare infrastructure in the region. Furthermore, factors like expanding RD infrastructure, significant investments by key market players, the growing biopharmaceutical industry, and the increasing skilled workforce are also likely to catalyze the market's growth.

The downstream processing market for the Rest of the World is projected to register substantial growth over the review timeframe owing to the advancements in chromatographic techniques, booming biotechnology sector, the growing adoption rate of the bioprocessing technology by biopharmaceutical companies and increasing per capita spending of the populace in the healthcare sector.

Competitive Analysis

The global market for downstream processing has a substantially intense competitive landscape. The analysis by MRFR reveals several strategies and new techniques being implemented by the players in the market to grow business globally. The list of leading players in the downstream processing market includes companies such as Asahi Kasei Corporation (Japan), Eppendorf AG (Switzerland), Boehringer Ingelheim (Germany), Danaher Corporation (US), Sartorius Stedim Biotech S.A. (France), Corning Incorporated (US), Lonza Group AG (Switzerland), 3M Company (US), Merck Millipore (Germany), Thermo Fisher Scientific Inc. (US), and several others.