Creative Biostructure has a comprehensive computer-aided drug design (CADD) platform, which enables us to offer custom in silico virtual screening services. The optimized virtual screening procedure can reduce the number of compounds to be experimentally screened, improve the possibility of ideal lead discovery, and reduce the risk of failure of later lead optimization, thereby winning valuable time for your project on the development of novel drugs. in silico drug design https://drug-discovery.creativ....e-biostructure.com/i

The process of looking for a new drug against a specific target for a certain disease commonly involves high-throughput screening (HTS), wherein large libraries of chemicals are tested for their ability to modulate the biological activity of the target. For instance, if the target is a novel GPCR, compounds will be screened for their ability to inhibit or stimulate the receptor; if the target is a protein kinase, the chemicals will be tested for their ability to inhibit the kinase. Creative Biostructure provides custom high-throughput screening services, and our biochemical/cell-based HTS technologies allow us to efficiently screen hits from a variety of compound libraries. high throughput screening platform https://drug-discovery.creativ....e-biostructure.com/h

Creative Biostructure has established a MagHelix™ FBDD Platform for early drug discovery, which covers advanced biophysical detection instruments, such as the X-ray single crystal diffractometer, high-performance nuclear magnetic resonance (NMR) instrument, and surface plasmon resonance (SPR) instrument. With the FBDD platform, we can provide customized drug discovery solutions for a wide variety of disease areas and therapeutic targets, including complex targets involving protein-protein interactions (PPI). Fragment-based drug discovery https://drug-discovery.creativ....e-biostructure.com/m

Creative Biostructure’s platform covers all the mainstream technologies needed to successfully determine the 3D structure of biological macromolecules. Relying on this platform, we can provide a one-stop gene-to-protein and gene-to-structure solution. Over the past decades, we have accumulated a wealth of experience in structural analysis of receptors, enzymes, ion channels, antigens, viruses, and other targets. Listed below are some of our resources and platform equipment for structure determination. Structure-based drug discovery https://drug-discovery.creativ....e-biostructure.com/m

Interactions between biological macromolecules regulate various biological processes. Many molecular biology and biochemistry methods have been developed to detect this interaction, such as pull-down assay, co-immunoprecipitation (Co-IP), yeast two-hybrid analysis, surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC). However, fluorescence resonance energy transfer (FRET) technology has gained great popularity due to its ability to detect interactions with extremely high spatiotemporal resolution in physiological conditions in a non-invasive manner. As an expert in structural biology and protein research, Creative Biostructure is helping our customers with diverse basic and preclinical research services targeting coronavirus infections, including COVID-19. We offer FRET technology-based assay development and detection services for coronavirus research. Coronavirus FRET Assay https://www.creative-biostruct....ure.com/coronavirus/